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Fluconazole is available in a variety of dosages ranging from 50 to 400 mg (milligrams) daily. A healthcare provider may change your dosage depending on the severity of your infection. You may start with a higher dosage of 400 mg and gradually be prescribed a lower dosage.

You can take a missed dose as soon as you remember unless it is near the time of your next dose. If close to the time of your next dose, continue with your regular dosing schedule.

A healthcare provider may not recommend fluconazole if you have a history of the following:

• Arrhythmia (irregular heartbeat)
• Low calcium levels
• Cancer treatment
• AIDS

Fluconazole is not a controlled substance.

If you are pregnant or planning to become pregnant, you should not take fluconazole during your pregnancy. Fluconazole may secrete into breast milk. Still, there is limited research on the effect of fluconazole in pregnant individuals. In some cases, a healthcare provider may recommend a smaller dose of fluconazole.

Drinking alcohol while taking fluconazole may increase your risk of side effects and liver damage.

While weight gain is not a common symptom of fluconazole, it’s possible to see changes in your weight while taking the medication.

On average, fluconazole is prescribed for weeks or months, depending on the severity of your infection. There is an increased risk of side effects if you use fluconazole for longer. Be sure to follow directions from a healthcare provider on how long to take fluconazole. Finish treatment even if you start to feel better before the recommended time frame. Long-term use of fluconazole may require additional supervision by a healthcare provider.

Fluconazole is only used to treat fungal infections, like urinary tract infections, oropharyngeal and esophageal candidiasis, peritonitis (inflammation in the abdominal lining), and any Candida infections.

Fluconazole begins working as soon as one to two hours after ingesting the medication. You may see improvements within a couple of days of starting the medication.

No foods directly interact with fluconazole. However, reducing your sugar intake may help with managing Candida overgrowth.

Fluconazole can treat skin and nail fungal infections. It’s typically given as a daily treatment with a varying dosage based on a healthcare provider’s recommendations.

The following side effects may occur while taking fluconazole:

• Headaches
• Heartburn
• Abdominal pain
• Diarrhea
• Dizziness

It’s important to know that not everyone will experience the same side effects while taking fluconazole. If you experience these or any additional symptoms, reach out to a healthcare provider.

Severe side effects that can happen while taking fluconazole include:

• Seizures
• Loss of appetite
• Extreme fatigue
• Blisters
• Hives
• Swelling
• Jaundice (yellowing of the skin and eyes)
• Difficulty breathing
• Kidney damage

Fluconazole may interact with certain NSAIDs (nonsteroidal anti-inflammatory drugs) like ibuprofen (Advil). Naproxen (Aleve) may also negatively interact with fluconazole. Fluconazole (Diflucan) may also interact with pain medications, blood thinners, vitamin supplements like vitamin A, and more. Be sure to check with your healthcare provider before taking another medication at the same time as fluconazole.

Yes! With LifeMD, you can connect with a licensed healthcare provider from the comfort of your home within an hour. If appropriate, your provider may prescribe fluconazole and send it directly to your local pharmacy.

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